Séminaires

Les séminaires de recherche à l'IRIM

Les séminaires à l’IRIM ont lieu tous les vendredis à 11h00 dans la salle « Marcel Dorée ». Il y a une alternance entre séminaires internes faits par les équipes et les séminaires externes sur invitation (voir liste ci-dessous).

Début 2019, l’IRIM a également lancé une nouvelle série séminaire 'career outside academia seminars’ visant à présenter aux doctorants et postdoctorants du campus les parcours professionnels possibles en dehors de la recherche académique, après un doctorat et post-doctorat. Ces séminaires ont lieu dans un contexte informal et détendu, laissant libre cours aux questions et discussions. Plus d'information ici.

Futures séminaires :

  • Dr. Jost Enninga (Institut Pasteur, Paris) "Subversion of infection associated macropinosomes drives the intracellular niche formation of bacterial pathogens" - 5 Juillet 2019

Jost Enninga heads the research unit « Dynamics of host-pathogen interactions » within the Department of Cell Biology and Infection at the Institut Pasteur in Paris. He performed his Ph.D. studies in the Laboratory of Cell Biology at the Rockefeller University, New York, under the supervision of Dr. Guenter Blobel. There, he focused on how viruses subvert host cellular trafficking processes. Afterwards, Jost moved to the Institut Pasteur in Paris in 2004 to study the early events of bacterial host cellular invasion with Dr. Philippe Sansonetti and Dr. Guy Tran Van Nhieu. Between 2008 and 2012, Jost built up his own junior team at the Institut Pasteur, and he heads his current research unit since 2013. His team investigates the intracellular niche formation of different bacterial pathogens, including Shigella and Salmonella.  Main questions are membrane trafficking subversion by the pathogens, and how specific intracellular localizations trigger distinct immune responses. His research unit develops imaging-based technologies that allow the analysis of host-pathogen interaction dynamics with unprecedented spatiotemporal resolution.

Summary of the seminar: Enteroinvasive pathogens, such as Shigella and Salmonella, induce their uptake into non-phagocytic epithelial cells through the injection of effectors by the type-3-secretion system. The bacteria are ingested in tight bacterial-containing vacuoles (BCVs) that are surrounded by in situ formed infection-associated macropinosomes (IAMs). In contrast to previous reports, we have recently shown via novel 3D imaging techniques that macropinocytosis is not required for the entry of these bacterial pathogens, however the IAMs regulate their subsequent intracellular trafficking. In the case of Shigella, we have revealed that IAMs do not fuse with the BCV, and that contact between these two compartments results in the destabilization of the BCV and membrane rupture. In the case of Salmonella two scenarios occur; IAMs either fuse with the BCV, which results in the generation of the Salmonella containing vacuole surrounded by Salmonella induced filaments (Sifs). In contrast, simple contact between IAMs and the BCV leads also to vacuolar rupture in the case of Salmonella and its cytoplasmic hyper-replication. We have performed ultra-structural studies, combined with dynamic imaging and proteomics of the involved compartments to identify the molecules that drive these interactions. This has shown a regulatoy network of Rab GTPases, the Exocyst complex, and SNAREs that is hijacked by injected bacterial effectors. I will describe how these factors determine the intracellular niche formation for both, Shigella and Salmonella.

  • Dr. Pierre-Olivier Vidalain (CIRI) "Searching for chemical activators of the interferon response : surprises from a chemobiological approach" - 13 Septembre 2019

Pierre-Olivier Vidalain, Directeur de Recherche, CNRS. Après avoir soutenu une thèse en immunologie à l’Ecole Normale Supérieure de Lyon, Pierre-Olivier s’est familiarisé avec les techniques de criblage à haut débit et l’étude des interactions protéine-protéine dans l’équipe de Marc Vidal (Harvard Medical School, Boston). Recruté en 2005 au CNRS, il a travaillé successivement à l’Institut Pasteur puis à l’Université Paris Descartes où il a étudié les interactions entre protéines virales et cellulaires et à mis au point différents systèmes pour l’identification de molécules antivirales ciblant l’hôte. Il s’intéresse plus particulièrement aux effets immunomodulateurs de composés inhibant la voie de biosynthèse des pyrimidines. En janvier 2019, il a rejoint le Centre International de Recherche en Infectiologie à Lyon pour poursuivre ses travaux à l’interface entre immunité innée, métabolisme et approches chémobiologiques

  • Prof. Ricardo Soto-Rifo (Universidad de Chile) "The complex life of HIV-1 full-length RNA" - Mardi 1er octobre 2019, 14h
  • Dr. Padilla Sergi (University of Oxford) "Glycolytic activity regulates membrane tension to facilitate HIV-1 fusion" - octobre 2019
  • Dr. Sarah Gallois-Montbrun (Institut Cochin, Paris) "Title to be announced" - 13 décembre 2019

Séminaires passés :

  • Dr. F. Perez (Institut Curie, Paris) "Exploring the Secretory Pathway : from Basic to Translational Research" - 28 Juin 2019

Dr. Franck Perez is Research Director at CNRS and Chairman of the "Cell Biology and Cancer" Unit of the Institut Curie in Paris. His group is studying intracellular trafficking with an important focus on the development of new methods and tools for Cell Biology studies. For example, he developed at the Institut Curie the use of automated cellular screening and co-founded a High Content screening platform (BioPhenics, with Dr. J. Camonis). In addition, his group created a novel trafficking assay and have strongly invested on the development of recombinant antibodies for cell biology. Recently, he created a novel antibody library based on a humanized nanobody scaffold and created a therapeutic antibody platform.

Dr. F. Perez is Scientific Director of the cell screening platform Biophenics and of the Therapeutic Antibody platform TAbIP and the head of the "Dynamics of Intracellular Organization' team at the Institut Curie. He authored more than 90 scientific articles, developed free software and filled several patents. He is a co-founder of Start-up in the field of immuno- and cellular-therapies, Honing Biosciences.

  • Dr. Sylvie Lecollinet (Virology department at ANSES/Veterinary school, Maisons-Alfort) “From basic to applied research on zoonotic West Nile and Usutu flaviviruses” - 14 Juin 2019
  • Dr. Niedergang Florence (Institut Cochin - Paris) "Macrophages upon viral infection, emergence of opportunistic diseases" - 9 Mai 2019
  • Dr. Mauffret Olivier (LBPA - ENS Cachan) "Structures-functions relationships of the zinc fingers domains of HIV-1 nuclecocapsid protein" - 15 Février 2019
  • Dr. Manel Nicolas (Institut Curie) - "Activation of innate immune sensors by viruses and self" -1er Février 2019
  • Dr. Carocci Margot (INSERM UMR-949, Université de Strasbourg) "Development of novel strategies to fight flaviviruses: from targeted screen to in vivo antiviral validation" - 7 Décembre 2018
  • Dr. Cimarelli Andrea (Inserm U1111 - CNRS UMR 5308 - Université / ENS de Lyon) "Interferon-stimulated transmembrane proteins (ifitms) as a novel paradigm of restriction factors targeting the in and out of a viral life cycle" - 14 Novembre 2018
  • Dr. Margottin-Goguet Florence (Institut Cochin - Paris) "HIV Latency as an intrinsic host defense antagonized by lentiviral proteins" - 21 Septembre 2018
  • Dr. Oehlers Stefan (Centenary Institute - University of Sidney) "Vascular control of mycobacterial immunity" - 6 Juillet 2018
  • Dr. Shu Sin Chng (Department of Chemistry, National University of Singapore) "Bacterial lipid trafficking and outer membrane homeostasis"
  • Prof. Slupphaug Geir (Department of Clinical and Molecular Medicine, Trondheim, Norway) "Are endogenous and chemically induced base methylations in human mRNA processed differentially?"
  • Dr. Chojnacki Jakub (IrsiCaixa AIDS research institut - Barcelona) "STED microscopy studies of HIV-1 dynamic structure and virus-cell interactions."
  • Dr. Gaudin Raphaël (Inserm U1110 - Strasbourg) "Zika virus induces monocyte transmigration, spreading the infection to the brain"
  • Dr. Muriaux D.  (CEMIPAI) "Présentation de la plateforme CEMIPAI et ses technologies innovantes"
  • Prof. Yegutgin G. (University of Turku - Finland) "Emerging roles of purine-converting ectoenzymes in inflammation and tumorigenesis"
  • Dr. Smyth R. (IBMC, Strasbourg)
  • Dr. Lyonnais S. (IBMB-CSIC, Barcelone)
  • Dr. Long J. (Imperial College of London)
  • Dr. Meunier E. (IPBS, Toulouse)
  • Dr. Herbeuval J.P. (UMR 8601, Paris)
  • Dr. Wodrich G. (UMR 5234, Bordeaux)
  • Dr. Henriet S. (University of Bergen, Norway)
  • Dr. Janvier K. (Institut Cochin, Paris)

     
   

   

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IRIM
Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5
FRANCE

 

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