News

Eric Martinez publishes his work in « Autophagy » (IF=11.06)

The team “Cell biology of bacterial infections” has demonstrated that the bacterial effector protein CvpF stimulates autophagy and promotes the anchoring of LC3B-II to Coxiella burnetii’s replicative niche, by deriving the function of the RAB GTPase RAB26.

https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1728098
Importantly, CvpF plays a major role in the virulence of Coxiella burnetii in vivo. The approaches developed allow to understand how Coxiella manipulates cellular mechanisms, such as autophagy, to establish a replicative niche and develop in cells. Ultimately, a better understanding of the Coxiella burnetii infectious cycle will allow the development of anti-infectious molecules targeting both infected cells and the pathogen.


     
   

   

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IRIM
Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5
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