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PUBLICATION IN NATURE MICROBIOLOGY (IF=14.2)

Raphaël GAUDIN, in collaboration with Jean-Pierre Vartanian’s team of Institut Pasteur, publishes an article in Nature Microbiology: https://www.nature.com/articles/s41564-019-0405-x

In this paper, both teams have demonstrated that a cellular protein capable of degrading DNA could be incorporated into the viral particle and induces degradation of the hepatitis B virus genome. In this process, the enzyme, known as DNase I, produces empty virus particles. DNase I, considered as a new antiviral restriction factor, is expressed in vitro in a hypoxic (oxygen-depleted) environment and also in patients infected with hepatitis B virus.


     
   

   

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