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CHALOIN Laurent


Position

Director of Research CNRS - HDR

Team

Bacterial Enzymes and Antibiotics Resistance

Contact

email : laurent.chaloin(at)irim.cnrs.fr

Tel : 04 34 35 94 66

 

Research projects:

1) Developement of allosteric inhibitors against human 5'-nucleotidases to limit resistance to cancer treatments or to restore the anticancer immune response.

2) Molecular mechanisms involved in antibiotics resistance 

 

5 relevant publications :

  1. Rahimova R, Fontanel S, Lionne C, Jordheim LP, Peyrottes S, Chaloin L. "Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface" PLoS Comput Biol. (2018)14:e1005943. Pubmed

  2. Leban, N., Kaplan E., Chaloin L., Godreuil S. and Lionne C. “Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases” Biochim Biophys Acta. (2017), 1861, 3464-3473. Pubmed

  3. Morichaud Z., Chaloin L. and Brodolin K. “Regions 1.2 and 3.2 of the RNA polymerase subunit promote DNA melting and attenuate action of the antibiotic lipiarmycin.” J. Mol. Biol. (2016) 428, 463-76, doi: 10.1016/j.jmb.2015.12.017. Pubmed

  4. Marton Z., Guillon R., Krimm I., Preeti, Rahimova R., Egron D., Jordheim L.P., Aghajari N., Dumontet C., Périgaud C., Lionne C., Peyrottes S. and Chaloin L. “Identification of non-competitive inhibitors of cytosolic 5'-nucleotidase II using a fragment-based approach.” Med Chem. (2015) 58, 9680-96  Pubmed

  5. Jordheim, L.P. and Chaloin L. "Therapeutic perspectives for cN-II in cancer" Current Medicinal Chemistry (2013), 20, 4292-4303. Pubmed


     
   

   

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IRIM
Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5
FRANCE

 

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