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Arhel Nathalie


Position

CNRS tenured researcher

Team leader

Team

Viral Trafficking, Restriction and Innate Signaling (VTRIS)

Contact

email : nathalie.arhel[at]irim.cnrs.fr

Tél : 04 34 35 94 53

 

Publications

ORCID  : 0000-0001-5309-1725

Fernandez J, Machado AK, Lyonnais S, Chamontin C, Gärtner K, Léger T, Henriquet C, Garcia C, Portilho DM, Pugnière M, Chaloin L, Muriaux D, Yamauchi Y, Blaise M, Nisole S, Arhel NJTransportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating. Nat Microbiol. 2019 Oct 14.

Nisole S, Fernandez J, Maarifi G, Arhel NJSUMO regulates the capacity of TRIM5α to inhibit HIV-1. Med Sci (Paris). 2019, 35(2):106-109. 

Maarifi G, Fernandez J, Portilho DM, Boulay A, Dutrieux, J, Oddos S, Butler-Browne G, Nisole S, Arhel NJRanBP2 regulates the anti-retroviral activity of TRIM5α by SUMOylation at a predicted phosphorylated SUMOylation motif. Commun Biol. 2018, 1:193.

Portilho DM, Fernandez J, Ringeard M, Machado AK, Boulay A, Mayer M, Müller-Trutwin M, Beignon AS, Kirchhoff F, Nisole S, Arhel NJEndogenous TRIM5α function is regulated by SUMOylation and nuclear sequestration for efficient innate sensing in dendritic cells. Cell Reports. 2016, 14(2):355-69.

Portilho DM, Persson R, Arhel NRole of non-motile microtubule-associated proteins in virus trafficking. Biomol Concepts. 2016, 7(5-6):283-292.

Dutrieux J, Maarifi G, Portilho DM, Arhel NJ, Chelbi-Alix MK, Nisole S. PML/TRIM19-dependent inhibition of retroviral reverse-transcription by Daxx. PLoS Pathog. 2015, 11(11):e1005280.

Fernandez J, Portilho DM, Danckaert A, Munier S, Becker A, Roux P, Zambo A, Shorte S, Jacob Y, Vidalain PO, Charneau P, Clavel F, Arhel NJMicrotubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. J Biol Chem. 2015, 290(8):4631-46.

Kotera N, Dubost E, Milanole G, Doris E, Gravel E, Arhel N, Brotin T, Dutasta JP, Cochrane J, Mari E, Boutin C, Léonce E, Berthault P, Rousseau B. A doubly responsive probe for the detection of Cys4-tagged proteins. Chem Commun. 2015, 51(57):11482-4.

Gaudin R, de Alencar BC, Arhel N, Benaroch P. HIV trafficking in host cells: motors wanted! Trends Cell Biol. 2013, 23(12):652-62.

Di Nunzio F, Danckaert A, Fricke T, Perez P, Fernandez J, Perret E, Roux P, Shorte S, Charneau P, Diaz-Griffero F, Arhel NJHuman nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration. PLoS One. 2012, 7(9):e46037.

Lelek M, Di Nunzio F, Henriques R, Charneau P, Arhel N, Zimmer C. Superresolution imaging of HIV in infected cells with FlAsH-PALM. Proc Natl Acad Sci U S A. 2012, 109(22):8564-9.

Valle-Casuso JC, Di Nunzio F, Yang Y, Reszka N, Lienlaf M, Arhel N, Perez P, Brass AL, Diaz-Griffero F. TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core. J Virol. 2012, 86(10):5931-6.

Di Nunzio F, Félix T, Arhel NJ, Nisole S, Charneau P, Beignon AS.  HIV-derived vectors for therapy and vaccination against HIV. Vaccine. 2012, 30:2499-509.

Iglesias C, Ringeard M, Di Nunzio F, Fernandez J, Gaudin R, Souque P, Charneau P, Arhel NResidual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infectionRetrovirology. 2011, 8:92.

Arhel NRevisiting HIV-1 uncoatingRetrovirology. 2010, 7:96.

Arhel N, Kirchhoff F. Host proteins involved in HIV infection: new therapeutic targetsBiochim Biophys Acta. 2010, 1802(3):313-21.

Arhel NJ, Kirchhoff F. Implications of Nef: host cell interactions in viral persistence and progression to AIDSCurr Top Microbiol Immunol. 2009, 339:147-75.

Arhel N, Lehmann M, Clauss K, Nienhaus GU, Piguet V, Kirchhoff F. The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentivirusesJ Clin Invest. 2009, 119(10):2965-75.

Strauss G, Lindquist JA, Arhel N, Felder E, Karl S, Haas TL, Fulda S, Walczak H, Kirchhoff F, Debatin KM. CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signalingJ Exp Med. 2009, 206(6):1379-93.

Arhel NJ, Charneau P. Bisarsenical labeling of HIV-1 for real-time fluorescence microscopyMethods Mol Biol. 2009, 485:151-9.

Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC. The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infectionJ Virol. 2009, 83(1):73-80.

Arhel NJ, Nisole S, Carthagena L, Coutant F, Souque P, Brussel A, Estaquier J, Charneau P. Lack of endogenous TRIM5alpha-mediated restriction in rhesus macaque dendritic cellsBlood. 2008, 112(9):3772-6.

Genin E, Carion O, Mahler B, Dubertret B, Arhel N, Charneau P, Doris E, Mioskowski C. CrAsH-quantum dot nanohybrids for smart targeting of proteinsJ Am Chem Soc. 2008, 130(27):8596-7.

Kirchhoff F, Schindler M, Specht A, Arhel N, Münch J. Role of Nef in primate lentiviral immunopathogenesisCell Mol Life Sci. 2008, 65(17):2621-36.

Arhel N, Charneau P. Observation of the HIV-1 virus in infected cells using microscopy approachesPathol Biol (Paris). 2008, 56(1):1-3.

Arhel NJ, Souquere-Besse S, Munier S, Souque P, Guadagnini S, Rutherford S, Prévost MC, Allen TD, Charneau P. HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear poreEMBO J. 2007, 26(12):3025-37. Epub 2007 Jun 7.

Arhel N, Munier S, Souque P, Mollier K, Charneau P. Nuclear import defect of human immunodeficiency virus type 1 DNA flap mutants is not dependent on the viral strain or target cell typeJ Virol. 2006, 80(20):10262-9.

Arhel N, Genovesio A, Kim KA, Miko S, Perret E, Olivo-Marin JC, Shorte S, Charneau P. Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexesNat Methods. 2006, 3(10):817-24.

Arhel NJ, Souquere-Besse S, Charneau P. Wild-type and central DNA flap defective HIV-1 lentiviral vector genomes: intracellular visualization at ultrastructural resolution levelsRetrovirology. 2006, 3:38.

Clemo NK, Arhel NJ, Barnes JD, Baker J, Moorghen M, Packham GK, Paraskeva C, Williams AC. The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survivalBiochem Soc Trans. 2005, 33(Pt 4):676-8.

Barnes JD, Arhel NJ, Lee SS, Sharp A, Al-Okail M, Packham G, Hague A, Paraskeva C, Williams AC. Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cellsApoptosis. 2005, 10(2):301-11.

Arhel NJ, Packham G, Townsend PA, Collard TJ, H-Zadeh AM, Sharp A, Cutress RI, Malik K, Hague A, Paraskeva C, Williams AC. The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell linesInt J Cancer. 2003, 106(3):364-71.

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IRIM
Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5
FRANCE

 

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